The compressive strength and static biodegradation rate of chitosan-gelatin limestone-based carbonate hydroxyapatite composite scaffold

Background: One of the main components in tissue engineering is scaffold, which may serve as a medium to support cell and growth. Scaffolds must have good compressive strength controlled biodegradability show biological activities while treating bone defects. This study uses Chitosan-gelatin (C–G) with flexibility elasticity high-strength carbonate hydroxyapatite (CHA), be ideal scaffold for engineering. Purpose: To analyze static biodegradation rate within various ratios C–G CHA (C–G:CHA) requirement Methods: The synthesized from C–G:CHA three ratio variations, are 40:60, 30:70, 20:80 (weight weight [w/w]), made freeze-drying method. strengths then tested. tested by soaking simulated body fluid 1, 3, 7, 14, 21 days. Data analyzed one-way ANOVA parametric test. Results: each 40:60 (w/w), 30:70 consecutively, 4.2 Megapascals (MPa), 3.3 MPa, 2.2 there no significant differences p= 0.069 (p>0.05). percentage after days on variation (w/w) 25.98%, 24.67%, 20.64%. One-way Welch test shows result p-value p<0.05. Conclusion: variations 20:80(w/w) fulfilled requirements